Secure within a desolate home as an unnatural threat terrorizes the world, a man has established a tenuous domestic order with his wife and son, but this will soon be put to test when a desperate young family arrives seeking refuge.

An alcoholic drifter must battle withdrawal and psychotic rednecks after he becomes the target of a deranged sporting event.

FBI Agent Will Graham, who retired after catching Hannibal Lecter, returns to duty to engage in a risky cat-and-mouse game with Lecter to capture a new killer.