At a hospital in New York, Alex, a police officer, meets Leo, a boy who has the ability to get out of his body and pass through the walls like a ghost. Both team up with Mary, an intrepid journalist, to capture a disfigured villain who terrorizes the city.

First Lieutenant Shun'ichi Maki of the Japan Air Self-Defense Force is a prestigious F-15 Eagle jet pilot (or "driver" as he is called in the film). A lifelong fan of flying since he was a child, being a pilot is his ultimate dream. Unfortunately, his duties distance himself from his wife, Yoko, who always ends up being neglected, and his son, Tsugumu, who has a congenital blood disease and has a high risk of dying at a young age.Maki decides to quit the Air Force to devote more time to his family and to spend whatever is left for his son. He takes a part-time job as a commercial tour guide run by a kindly group of people who allow him time to work and to also take care of his family.

Three teenagers appear to have a lot of fun on the children's oncology department on the fourth floor of a large hospital. Nick and Iwan both lost a leg as a result of bone cancer. For their friend Olivier, an amputation may be the next phase. The fourth of the bunch, Pepijn, is so ill and weak that he often stays in his room. Friendship and a deep desire to live keeps the guys mentally balanced. Their friendship changes when Gina arrives. Sickos is a humorous drama that deals with adolescence and chemotherapy.