MIDNIGHT OXYGEN follows a group of friends celebrating a reunion inside of a LAKE HOUSE until an astronomical event unravels on the lake, rippling the celebration into a nightmare that will forever alter the group.

Bruna is a biologist who studies insects. In 2020, during a pandemic, she faces a creative block to continue her current research. After talking to her advisor, Dr. Jaime, Bruna is pressured to look for new stimuli to write. After a few attempts, the young scientist ends up transforming in an irreversible way.