Matt Burns is many things — loser, dork, pizza delivery boy — but a hero isn't one of them. That is, until he is forced to eat a genetically-engineered tomato that was designed to create super soldiers. A routine pizza delivery turns into a fight for his life, when he accidentally stumbles into the middle of a heated corporate takeover that plans on using this science for world domination. Now, equipped with an indestructible body, advanced strength and a pizza parlor mascot costume, Matt must use his new power to fight evil, rescue the girl and save the day as the unlikeliest of super-heroes: Pizza Man!

O universitário Matt Burns trabalha na pizzaria da mãe para ajudar a pagar os estudos. Sua vida simples e sem graça muda totalmente após um acidente que transforma o rapaz em um poderoso super-herói.