The story of Orochi revolves around the life of the Monzen family. Aoi Monzen, a famous, but aging, movie star and Kazusa and Lisa Monzen her two daughters. Aoi hopes for them both to take over her legacy as a star, but Kazusa does not live up to her expectations. The mother is always pitting the girls against one another competitively. As a result, as the years pass, the love the sisters shared grows to a hidden hatred. When another girl named Orochi saves the girl's mother from a terrible accident a bizarre chain of events is set in motion spanning many years. The atmosphere in their estate builds up until Orochi reveals a terrible truth that the family must keep hidden from the world. Orochi serves as the narrator of the story. The movie is based on a Kazuo Umezu manga series which ran from 1969 to 1970.

1950г. Орочи, таинственная девушка, приходит в поместье семьи Мондзен в поисках укрытия от грозы, и остается работать горничной. Хозяйка дома Аои Мондзен - молодая и успешная кинозвезда с двумя дочерьми. Но династия Мондзен хранит темную тайну, которая настигает всех, без исключения женщин, в чьих жилах течет эта кровь, по достижению возраста 29 лет…

每隔100年便沉睡的神秘少女阿蛇（谷村美月 饰）从恒久的睡眠中再次醒来。时为1950年，正是人气女优门前葵（木村佳乃 饰）风光无限的时候。因避雨的缘故，阿蛇躲进门前家，以女佣的身份留在了这里。葵有一草和理沙两个女儿，她对一草尤其严厉。楼上有一个房间禁止任何人进入，而里面有时而传出恐怖且痛苦的呻吟声。阿蛇发现，门前家似乎隐藏着某种可怕的秘密。直到某一天，葵突然隐退，阿蛇才开始了解萦绕在门前家这些美丽女人身上无法摆脱的厄运……