HexVet follows unlikely best friends Nan and Clarion as they navigate life's weird and wacky challenges, while apprenticing to be magical veterinarians for fantastical creatures. As HexVets in training, Nan and Clarion are ready to tackle medical maladies in beasts magical or mundane, find their familiars, and earn their wands and pointy hats--all while dodging covens of animal smugglers and dragons with heartburn. Under the tutelage of the talented Dr. Talon, these young HexVets in training will learn how to cure any animal, from a pygmy phoenix with bird flu to a unicorn with a broken horn.

You Gotta See This is an American reality television series produced by Comcast Entertainment Group for the Nickelodeon network. It premiered on July 21, 2012, directly after a marathon of SpongeBob SquarePants specials, movies and The Super Spongy Square Games. Just after 9 episodes, Nickelodeon cancelled You Gotta See This, they however aired the remaining episodes in UK and Ireland. It was hosted by Noah Crawford and Chris O'Neal.

Natalie's Backseat Traveling Web Show was a television series consisting of 3-minute shorts on Nickelodeon in the mid to late 1990s. The series was developed by Karen Fowler and Parker Reilly. The series was produced by Karen Fowler and directed by Mark Foster for Nickelodeon's Creative Labs. The website was written by Caitilin McAdoo and Carmen Morais, with web design and programming by Fusebox, Inc. The original scores were composed by Michael Aharon.

Its premise was centered around a preteen girl named Natalie who managed a live web diary while her family traveled across the United States while in the backseat of the family van. The character Natalie's web site, which later became Nick.com, would also contain games, photos, audio, and video clips along with written words about the character's thoughts and musings. The website and television shorts launched simultaneously in 1996, as both correlated with the other. The show was created before weblogs, audioblogs, photo blogs, and vlogs rose in popularity in the 2000s.

The Let's Just Play Go Healthy Challenge is a reality television series, which airs on Nickelodeon. Each season follows kids over a six-month period in the quest to make their lives healthier.

U to U, sometimes labeled as U-2-U, is a weekly Nickelodeon television series that aired from 1994 to 1996. The show focused on displaying viewer-submitted work and ideas in their "Straight From U" segment where viewers were able to submit their work via mail, e-mail, fax, or telephone.

The show included short stories and comic strips written by viewers that were turned into animated shorts, and songs that were written and made into music videos. The interaction of series allowed viewers to play games over the phone, ask questions to celebrities, meet pen pals from other countries, and read letters aloud.

The show also featured an online presence in the Prodigy Internet service where viewers could create and send content for show consideration as well as participate in bulletin board conversations.

You're On! is an American television game show aired from 1998–1999 on Nickelodeon. The show took a premise similar to Candid Camera; however, to adopt the format better for a children's game show, You're On! featured youth contestants trying to convince a passersby to complete a series of predetermined tasks while unknowingly on camera.

The show was taped in Soundstage 18 of Nickelodeon Studios Florida and was hosted by Phil Moore. The remote hosts for You’re On! were Vivianne Collins and Travis White. These two would brief the kids on their tasks, congratulate them when all three tasks were completed, or let them know time was up.

Reruns of You’re On! have aired on Nickelodeon Games and Sports for Kids. It was dropped from the schedule on November 26, 2004.

Think Fast is an American children's game show which aired on Nickelodeon from May 1, 1989 to June 29, 1991.

For the first season, the show was hosted by Michael Carrington, and announced by James Eoppolo. When the show moved to the new Nickelodeon Studios in Orlando, Florida for season two, Eoppolo was invited to stay on as announcer but was contractually obligated to another project by that time. Carrington was replaced by Skip Lackey and the new announcer was Henry J.

The show's theme music was composed by Edd Kalehoff.

Make the Grade is a children's game show that aired from October 2, 1989 through December 29, 1991 on Nickelodeon.

Worldwide Day of Play is an annual event designed to encourage children and parents to turn off the television and play, especially outdoors. The yearly event officially began on all US Nickelodeon channels: Nickelodeon, Nick GAS, Noggin, The N, and NickToons on October 1, 2005. The event was first shown on October 2, 2004 on Nickelodeon. Some foreign versions of Nick also participated. The event is designed as a finale for Nick's six-month long Let's Just Play campaign. In addition, Nick.com would also have special features for children to learn how to stay active and healthy.

The Big Green Help is a reality television series that airs on Nickelodeon. The program shows how kids can find a way to take care of the Earth.

Slime Time Live is a television series that aired on Nickelodeon from 2000–2003, lasting 8 seasons. During its run it was hosted by Dave Aizer, Jonah Travick and Jessica Holmes and produced/directed by Jason Harper. It was located outside of the former Nickelodeon Studios at Universal Studios Florida. It mainly aired as filler during regular commercial time.

The show holds two Guinness World Records – most people pied in three minutes, and most people slimed. The sliming was done outdoors, in front of the studios.

SK8-TV is a program shown on Nickelodeon that began in 1990 and was originally hosted by Matthew Lillard and Skatemaster Tate. It was a skateboard variety show that featured on-set interviews as well as off site action segments. Various techniques were introduced to television in SK8-TV including hand-held cameras and the use of multi-format film and video. The set for the show was built on location at the Pink Motel in Sun Valley California which was famous for its large fish shaped pool that was ideal for skateboarding. It hosted a wide variety of skateboarders such as Christian Hosoi, Natas Kaupas, a young Tony Hawk and many others that went on to become famous and well known. It was created and produced by original Z-Boy Nathan Pratt and Mark Ashton Hunt from Binder Entertainment, directed by Stacy Peralta, who later went on to direct the retrospective documentary Dogtown and Z-Boys' with production design by C. R. Stecyk III. It later resurfaced on the now-defunct Nick GAS channel in 1999 and aired until 2005.

Indonesia Kids Choice Awards is Indonesian version of Nickelodeon Kids' Choice Awards, held since 2008 in Jakarta. And Indonesia is the second country in Asia who organized this award after Philippines.

Following year, the event was again held on July 23, 2009 which took place in Tennis Indoor Senayan, Jakarta with the host by Raffi Ahmad, Ipank and Fitri Tropica.

On May 9, 2010, the event was held again in Tennis Indoor Senayan. 2010 edition of this event is the first brought by four people show host.

Rock 'n' roll duo and best friends Jonny and Matty, a.k.a. The BeatBuds, are traveling to their big concert, The BeatBASH. As they journey to the show in The Beat Bus, they have awesome fun-filled experiences making new friends and performing their songs with everyone and everything they encounter.

Purple and Brown is a claymation short television series devised and directed by Rich Webber and edited by Mike Percival. The series first aired March 2006, on the Nickelodeon's United Kingdom channel, and later became a staple on the American Nickelodeon network as part of its former Nick Extra short program.