Lingo is an American television game show with multiple international adaptations. The first American version aired from 1987 to 1988 in syndication, a second version of the show ran as an original series on GSN for six seasons from 2002 to 2007, and a third version began airing on GSN on June 6, 2011.

The game features two teams of two contestants each who attempt to guess five-letter words and use colored balls to place markers on a 5×5 numbered Lingo card, attempting to cover five spaces in a row in a fashion similar to bingo.

An All Hallows Eve presentation of GSN's Game Show Saturday Night broadcast on 28 October 2000. Elvira, the Queen of Halloween, gravely unearths the dead-before-arrival game show pilots Cop Out, The $10,000 Sweep, Twisters and The Riddlers for a bewitching programming trick.

Clad in her signature "little black dress," Elvira introduces each pilot and teases viewers with a trivia question before fading into the night. After each show, she mysteriously reappears to reveal the answer.

Whammy! is an American television game show that aired new episodes on Game Show Network from April 15, 2002 to December 5, 2003. The program is updated version of Press Your Luck, which originally aired on CBS from 1983–86. Reruns of Whammy! have aired since production of new episodes stopped in 2003, and the program currently airs in reruns on GSN weekend mornings at 9:30am Eastern/8:30am Central.

The series was taped at Tribune Studios and was hosted by Todd Newton, with Gary Kroeger announcing.

Four contestants compete for up to $100,000 in a hybrid general knowledge quiz-game of chance. They stand on a giant 6-panel roulette board, similar to a chamber of a revolver, where wrong answers could eliminate a player by causing them to drop out of the game – literally.

Dog Eat Dog is an American game show, which originally ran from June 17, 2002 to August 26, 2003. It is loosely based on the UK version of the show by the same name. It is hosted by Brooke Burns, and has contestants compete against each other in physical competitions, trivia, and other assorted games for a prize of $25,000.

Reruns of Dog Eat Dog currently air on the Game Show Network.

Cram is a game show that aired as an original series for GSN in 2003. The show featured two teams, each composed of two contestants. For 24 hours before taping, the contestants were sequestered in a warehouse, with the intent of staying awake and "cramming" various material such as trivia questions and jokes, which they would then answer on the show while attempting physical stunts in an attempt to stay awake. Graham Elwood was the host and Berglind Icey was the co-host.

National Lampoon's Funny Money is a comedy game show that aired on GSN from June 15 to October 24, 2003. The show was hosted by stand-up comedian Jimmy Pardo, and Budd Friedman served as the announcer.

Extreme Dodgeball is an American Sports Entertainment television show that debuted on Game Show Network in 2004. It has also been shown in the UK on Challenge.

Celebrity Blackjack was a television show on GSN where celebrities played tournament style blackjack for charity. The show was hosted by Matt Vasgersian. Dave Stann was the dealer. Season 1 aired weekly from July 5 through August 9, 2004. Season 2 premiered October 12, 2004 and ran weekly through January 11, 2005.

Ballbreakers is a pocket billiards game show that began on the Game Show Network on July 18, 2005. The hosts were Sal Masekela, Ewa Mataya Laurance, and Adrianne Curry. GSN cancelled the show in 2006.

High Stakes Poker is a cash game poker television program, which was broadcast by the cable television network GSN in the United States. The poker variant played on the show is no limit Texas hold 'em. It premiered on January 16, 2006 and ended on December 17, 2007 for the first 4 seasons and the last 3 seasons ran from March 1, 2009 to May 21, 2011 and was simulcast in 3DTV on N3D.

The participants on the show include both professional poker players and amateur players.

The show was hosted by AJ Benza in the first five seasons, alongside Gabe Kaplan. Starting with the sixth season, Kara Scott replaced Benza as Kaplan's co-host, with Scott conducting interviews from the poker room floor. Starting with the seventh season, Norm Macdonald replaced Gabe Kaplan as Scott's co-host. In 2020, after a nine year hiatus, the show returned with the original commentary duo of Benza and Kaplan.

PlayMania is a live interactive game show on GSN, hosted by Mel Peachey, Shandi Finnessey, Jessica York, Angelle Tymon and Jeff Thisted. The two-hour program featured interactive games that the viewers could play to win cash prizes. On February 20, 2007, the show was replaced with two separate programs, quiznation and 100 Winners which were collectively known as the PlayMania Block.

Starface is an American television game show which ran on GSN on August 1, 2006 to November 4, 2006. Reruns aired until January 2007.

Grand Slam is an American game show based on the British series of the same name. Unlike the British series, which was played as a regular quiz show, the American version was conducted as a super tournament featuring contestants who had earlier appeared on other game shows.

Grand Slam aired on GSN for eight episodes from August 4, 2007 until September 8, 2007. Dennis Miller and Amanda Byram hosted the program but did not participate in the games themselves, instead providing commentary in between rounds. The questions were asked by Pat Kiernan, who was never seen on camera. The series is produced by Embassy Row Productions in association with Sony Pictures Television and GSN. Legendary Jeopardy! champion Ken Jennings was the winner of the Grand Slam tournament, defeating Ogi Ogas in the final round.

Bingo America is an American game show airing on GSN that follows two contestants as they try to compete to win up to $100,000, as well as letting at-home viewers print bingo cards at GSN.com that allow them to play along with the show to win money.

Created and produced by veteran television producer Andrew Glassman, the show was originally hosted by Patrick Duffy and Crystal Wallasch. When its second season premiered on October 6, 2008, they were replaced by Richard Karn and Diane Mizota, respectively.

20Q is an American game show based on the online artificial intelligence and handheld computer game of the same name. Licensed to and produced by Endemol USA, it premiered on June 13, 2009 during Big Saturday Night airing on GSN, and is hosted by Cat Deeley of So You Think You Can Dance with the voice of the computer provided by Hal Sparks.

In Argentina, the name of the show is Flor de palabra; it is hosted by Florencia Pena and Richard Rubin of Beauty and the Geek.

Instant Recall is an American hidden camera, game show hosted by Wink Martindale. The series premiered on GSN on Thursday, March 4, 2010 at 8:30 p.m., with a new episode airing each Thursday for eight weeks. The show features contestants who are placed in unusual situations and are filmed with a hidden camera. The contestants are then tested on what they just experienced to see how good their memories are. The more correct answers they provide, the more cash and prizes they win.

Instant Recall is the first game show hosted by Martindale since Debt aired on Lifetime from 1996 to 1998.