John Morris Henson (born July 11, 1967) is an American comedian, actor, and talk show host. Henson began his career as a stand-up comic. He started appearing in films in the mid to late 1990s. He was the longest-running host (four years) of Talk Soup on the E! Entertainment Network, hosting just over 1,000 shows in the four and a half years he was with the network. During his stint as host of Talk Soup, he appeared as a guest on Space Ghost Coast to Coast.

In 2004, he was the host of The John Henson Project, a short-lived comedy-reality show on Spike TV, and hosted several broadcast specials including ABC's Best Commercials You've Never Seen, ABC's Best TV You've Never Seen and, most recently, the 33rd Annual Daytime Creative Arts Emmy Awards. From 2005 to 2007, Henson was the co-host of Watch This!, a daily television show on the TV Guide Channel. Henson has also produced numerous field segments on the entertainment industry for MSNBC and CNN and, additionally, had a small recurring role as a local newscaster on My Name Is Earl.

From 2008 to 2014, Henson co-hosted the ABC obstacle course game-show, Wipeout, and always ended the show with the catch phrase, "Good night, and Big Balls", a reference to the signature obstacle in the show. From 2017 to 2021, Henson hosted Halloween Baking Championship on Food Network.

Henson has also appeared in the Blink-182 music video for "What's My Age Again?".