Jean Elizabeth Spangler (September 2, 1923 – disappeared October 7, 1949) was an American actress who appeared in bit parts in several Hollywood films in the late 1940s. She garnered public attention for her mysterious disappearance in late 1949.

On the evening of October 7, 1949, Spangler left her home in Los Angeles, telling her sister-in-law that she was going to meet with her ex-husband before going to work as an extra on a film set. She was last seen alive at a grocery store several blocks from her home at approximately 6:00 p.m. Two days later, Spangler's tattered purse was discovered in a remote area of Griffith Park, approximately 5.5 miles (8.9 km) from her home; inside was a letter addressed to a "Kirk", which mentioned seeing a doctor. Given Spangler's recent work on the film Young Man with a Horn starring Kirk Douglas, he called police to clear his name, telling them he was in Palm Springs at the time, which police accepted.

Spangler's disappearance generated various theories, which ranged from her alleged death in a botched abortion to her fleeing with Los Angeles gangsters with whom she was acquainted. To date, no additional evidence has been uncovered in Spangler's case, and her whereabouts remain unknown.