Scotty (at least one time every episode): Captain, the engines canna take anymore!

It would be easy to pick some of the quotes that are so engrained in our everyday lexicon, like Live long and prosper, or to Boldly go...

But I think some quotes that have resonated with me, are:

McCoy: It hurts, doesn't it? Spock: What would you have me say, Doctor?

Kirk: In every revolution, there is one man with a vision. Spock: Captain Kirk, I shall consider it.

Decker: You think I don't know that!? There was! But not anymore!!

Some fun ones:

Kirk: Right? Spock: Check.

Kirk: Check? Spock: Right.

Spock: Captain, you’re an excellent starship commander. But as a taxi driver, you leave much to be desired.

@Dark_Sithlord Here's another one my favorites:

In ST: The Search For Spock, after Kirk tells McCoy that the reason that Spock transferred his Katra into McCoy's minds:

McCoy: That green-blooded SOB! This is his revenge for all of those arguments I won!

Fasten your seatbelts, it's going to be a bumpy night.

One of my favorites from The Changling after Kirk talks Nomad into taking a deeper look at itself....

"Captain, your logic is impeccable. We are in grave danger."

McCoy from The Corbomite Maneuver (as he's talking to himself)...

"If I jumped every time a light came on around here I'd end up talking to myself."

In ST:TVH: When the crew are in present (1984) San Francisco and Kirk is trying to pawn his glasses:

Pawn Shop Clerk: "I'll give you one hundred dollars for them."

Kirk: "Is that a lot of money?"

Kelvin Timeline Spock: "I am a Vulcan. We embrace technicalities."

Kirk in ST V ;"Damn it, Bones, you're a doctor. You know that pain and guilt can't be taken away with a wave of a magic wand. They're the things we carry with us, the things that make us who we are. If we lose them, we lose ourselves. I don't want my pain taken away! I need my pain!"

I've always loved that quote, because it is so true

From the same movie;

McCoy: It's a song, you green-blooded... Vulcan. You sing it. The words aren't important. What's important is that you have a good time singing it.

Spock: Oh, I am sorry, Doctor. Were we having a good time?

McCoy: God, I liked him better before he died.

McCoy: "Dialysis? My god, what is this, the Dark Ages? We're dealing with medievalism here! Chemotherapy! Fundoscopic examinations!"

McCoy: I'll tell you one thing, Spock: You never cease to amaze me.

Spock: Nor I, myself.

McCoy: "Would you care for a drink, Mister Spock?"

Spock: "My father's race was spared the dubious benefits of alcohol."

McCoy: "Now I know why they were conquered."

@Nexus71 said:

Kirk in ST V ;"Damn it, Bones, you're a doctor. You know that pain and guilt can't be taken away with a wave of a magic wand. They're the things we carry with us, the things that make us who we are. If we lose them, we lose ourselves. I don't want my pain taken away! I need my pain!"

Great quote; but, doesn't sound very Kirk-like..."too deep". Shatner probably bullied the writers into taking it away from one of the other actors. Truth is, sounds more like the kind of counseling Bones would have given TO Kirk.

"Love sometimes expresses itself in sacrifice."

Kirk: You're not exactly catching us at our best.

Spock: That much is certain.