To treat an imprisoned mother, accused of trying to kill her daughter, Doc must fight against the prejudices of the entire hospital, just as he himself is being targeted by the investigation.

While our doctors are forced to take care of a patient, the rift between Doc and Carolina widens more and more, and Andrea must deal with himself.

Agnese is surprised to find Manuel's mother hospitalized, the child she has in foster care with Davide, and with whom things do not seem to go too well. Agnese will have to question everything she thinks she knows, just when Andrea seems to want to be closer to her than ever.

It's the day of the primary simulation for Doc: Andrea for a day returns to wear the gown, but a sudden computer blackout of the hospital's systems forces him to a series of risky choices.

While the doctors are busy solving the delicate case of a deafblind boy, Cecilia makes Doc an unexpected offer, triggering the jealousy of Agnese and Giulia.

Giulia is forced into a showdown with her cumbersome mother when her partner is hospitalized in the grip of an inexplicable syndrome. Just when Doc seems to be returning to primary, Cecilia discovers something compromising about him.

When he is one step away from regaining the primary, Doc is forced to a painful confession in front of the whole department.

Locked in the ward in a forced quarantine, doctors are engaged in a fight against time to stop a multidrug-resistant bacterium that has infected them all.