Pu Tao is a tough girl who grew up depending on no one. Her father left her family, then later her mother left at a boarding school while taking care of her autistic brother. After no contact for 17 years, her mother leaves her with two autistic children and her father shows up. Handling the betrayal of her parents and learning to take care of two autistic children while dealing with her own family problems.

袁卫国因不堪儿子孤独症折磨，与妻子离婚后又和新欢慧雅结合，抛弃了妻子与一双儿女。多年后，母亲病逝，巳成家的葡萄承抯起照顾哥哥袁望和被领养妹妹袁心的重任，为了患孤独症的哥哥，工作弄丟了，婆家人又不理解，葡萄只有顽强地坚持着。生活的艰辛磨砺了葡萄的性格，她从绝望中坚定了人生的信念，破茧化蝶般成为一个大爱无疆的女人。后来，袁卫国出现了，可当初负心的父亲已得了尿毒症，生命垂危，葡萄又一次站在了人生的十字路口上。面对曾经自私的父亲，还有趁人之危的小三，更有同父异母的弟妹，葡萄能否再次选择关爱与包容......