시즌 정규 출연진 6

1. 

   Hugh Laurie

   Gregory House

2. 

   Lisa Edelstein

   Lisa Cuddy

3. 

   Robert Sean Leonard

   James Wilson

4. 

   Omar Epps

   Eric Foreman

5. 

   Jennifer Morrison

   Allison Cameron

6. 

   Jesse Spencer

   Robert Chase

특별출연 12

1. 

   Peter Jacobson

   Chris Taub

2. 

   Olivia Wilde

   Thirteen

3. 

   Kal Penn

   Lawrence Kutner

4. 

   Rob Benedict

   Dr. Jaime Conway

5. 

   Jason Lewis

   Evan Greer / Dr. Brock Sterling

6. 

   Kristina Anapau

   Marie

7. 

   Anne Dudek

   Amber Volakis

8. 

   Kimberly Dawn Guerrero

   Anna

9. 

   Joe Marinelli

   Director

10. 

    Dominic Flores

    Pharmacist

11. Brett Ryback

    Salesman

12. Bobbin Bergstrom

    Nurse

제작진 10