Stała obsada sezonu 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liu

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Goście specjalni 13

1. 

   Rosanny Zayas

   Valentina Duran

2. 

   Michael Cerveris

   Councilman Ledesma

3. 

   Anne L. Nathan

   Moira Baker

4. 

   Luis Antonio Ramos

   Father Vega

5. 

   Elena Hurst

   Detective Lena Romero

6. 

   Francisco Burgos

   Cerio Cristobal

7. 

   Jason Alan Carvell

   Detective Grimes

8. 

   John Dossett

   Treadwell

9. 

   Merritt Janson

   Mallory

10. 

    Beth Fowler

    Anxious Woman

11. 

    Jorge Luna

    Cop

12. 

    Joseph Castillo-Midyett

    Cop

13. 

    Jordan Gelber

    Dr. Eugene Hawes

Ekipa 4