The doctors of Seattle Grace are faced with the aftermath of last season's plane crash. As they try to move on with their lives, they must learn to adapt to the changes, cope with their losses and move forward with their relationships and careers.

In this flashback episode, return to the site of the plane crash and watch as each doctor tries to cope with the heartache and injuries caused by the crash. Meanwhile, back at Seattle Grace, everyone struggles to find a bit of normalcy amidst the chaos.

The survivors from the crash are asked to make an almost impossible decision that will affect the rest of their lives. Meanwhile, tension grows between Jackson and April after they're forced to work together, and Alex tries to restrain himself with one of the interns.

Aware that Derek might never operate again, Meredith stops talking about the surgeries she's performing. Meanwhile, Richard calls on Dr. Catherine Avery to help him perform a complicated procedure, as things continue to heat up between Jackson and April; and Arizona's struggle to accept her fate forces Callie and Alex to face their guilt.

In this Meredith & Cristina-centric episode, the two friends continue to cope with life after the plane crash and their ever-growing responsibilities at their respective hospitals. As Meredith juggles taking care of Zola with a case that hits close to home, Cristina assists Dr. Thomas on a challenging heart surgery.

As the doctors continue with their lawsuit, they’re forced to confront the realities of their injuries. Meanwhile, Bailey tricks Arizona into helping her with a pediatric case, and Cristina tries to find normalcy in her new environment.

Cristina and Owen continue to figure out their relationship amidst the pending lawsuit; and Bailey argues with Ben over plans for their upcoming nuptials. Meanwhile, Callie recruits Jackson to help find a solution to Derek's hand, but he is preoccupied by a shocking situation with April.

The new batch of interns find themselves involved in all the drama at Seattle Grace: Meredith asks Heather to go above and beyond to help fix Derek's hand; Cristina starts a healthy competition between Stephanie and Leah, which inadvertently leads to a medical emergency for Cristina's patient; Alex sees Jo in a new light as they work to save a baby's life, and April teaches Shane a valuable lesson during "lumps and bumps" duty.

As the rest of the doctors prepare for Bailey's wedding, Richard helps her through a bout of pre-wedding jitters. Meanwhile, Lizzie butts heads with Meredith, and Callie and Jackson try to convince Derek to participate in a risky surgery that could fix his hand.

Bailey puts her wedding day on hold and continues her efforts to save Adele's life, Cristina and Owen remain undecided about their pending divorce, while Arizona and Callie try to get their spark back. Meanwhile, the hospital becomes inundated with a group of bikers after a horrible accident.

Meredith, Derek, Cristina and Arizona receive big news regarding the plane crash lawsuit, Richard avoids Catherine's romantic advances and Jackson takes on one of Mark Sloan's old patients. Meanwhile, Derek begins recovery on his hand.

The Seattle Grace doctors are on edge when a new medical professional enters the hospital; Arizona struggles with the emotional and physical pain of a phantom limb; and while battling pregnancy hormones, an overly-emotional Meredith is confronted with her worst fear.

As Derek and April work around the clock to find a solution for the hospital, Cristina struggles to respect the wishes of a family whose son is dying. Meanwhile, Arizona empathizes with a teenager who faces problems similar to her own.

Competition heats up as several of the doctors fight to become the new face of Seattle Grace; April brings in an emergency case, and Jackson and Alex work with a transgender teen couple. Meanwhile, the hospital implements new policies which test the patience of the staff.

Болницата се приближава до финансов крах и Оуен трябва да вземе трудни решения, в това число да отмени скъпа операция, която може да спаси живота на дете.

Новината за финансовите проблеми на "Сиатъл Грейс" се разпространява, Катрин насърчава Джаксън да се премести в Бостън, а стажантите се боят, че ще останат без работа.

Разнобоят и хаосът, причинени от новия управленски екип на болницата, карат един лекар да се съмнява в бъдещето си в "Сиатъл Грейс".

Болницата продължава да прави положителни промени при новото ръководство, но лекарите осъзнават, че собствеността е свързана със съвсем нови проблеми и отговорности.

Цистерна избухва на магистралата и ранява мнозина. Сред пострадалите е парамедикът Матю. Мередит и Джо помагат на разтревожена майка, чието дете страда от странна болест.

След като получават тревожна новина, Мередит и Дерек вземат превантивни мерки за бъдещето на децата си. Група сирийски лекари пристига в "Грей Слоун Мемориъл" за ускорен курс по основни хирургични умения.

След смъртта на няколко нейни пациенти Бейли се оказва мишена на разследване, водено от Центъра по заразни болести. Джак и останалите в борда спорят как да обяснят тази кризисна ситуация на обществеността.

Лекарите търсят Бейли, но тя продължава да изолира всички. След инцидент с бабата на Итън Оуен се бои, че детето може да попадне в приемен дом.

Лекарите в "Грей Слоун Мемориъл" се готвят за супербуря, която приближава Сиатъл. Желанието на Оуен да бъде родител се засилва със сближаването му с Итън.

"Грей Слоун Мемориъл" преминава на кризисен режим, докато бурята бушува. Ресурсите намаляват, а пациентите се увеличават. Междувременно един от лекарите се бори за живота си.