Elenco principal da temporada 5

1. 

   Seth MacFarlane

   Stan Smith / Roger (voice)

2. 

   Wendy Schaal

   Francine Smith (voice)

3. 

   Rachael MacFarlane

   Hayley Smith (voice)

4. 

   Scott Grimes

   Steve Smith (voice)

5. 

   Dee Bradley Baker

   Klaus (voice)

Convidados Especiais 7

1. Sabrina Alashi

   Hayley's daughter (voice)

2. 

   Stephen Merchant

   Scientist (voice)

3. 

   Max Charles

   Boy (voice)

4. 

   Patrick Stewart

   Avery Bullock (voice)

5. 

   Kevin Michael Richardson

   Principal Lewis (voice)

6. 

   Richard Kind

   Al Tuttle (voice)

7. 

   Jeff Fischer

   Jeff Fischer (voice)

Equipa técnica 3