Elenco principal da temporada 4

1. 

   Seth MacFarlane

   Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Tom Tucker (voice)

2. 

   Alex Borstein

   Lois Griffin / Tricia Takanawa / Loretta Brown / Barbara Pewterschmidt (voice)

3. 

   Mila Kunis

   Meg Griffin (voice)

4. 

   Seth Green

   Chris Griffin (voice)

Convidados Especiais 3

1. 

   Adam West

   Adam West (voice)

2. 

   Tony Sirico

   Vinny (voice)

3. 

   Yvette Nicole Brown

   Black Woman (voice)

Equipa técnica 2