Stała obsada sezonu 5

1. 

   Seth MacFarlane

   Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Tom Tucker (voice)

2. 

   Alex Borstein

   Lois Griffin / Tricia Takanawa / Loretta Brown / Barbara Pewterschmidt (voice)

3. 

   Mila Kunis

   Meg Griffin (voice)

4. 

   Seth Green

   Chris Griffin (voice)

5. 

   Mike Henry

   Cleveland Brown (voice)

Goście specjalni 4

1. 

   Frances Callier

   Shonda Rhimes (voice)

2. 

   Jonathan Kite

   Alec Baldwin (voice)

3. 

   Julie Bowen

   Julie Bowen (voice)

4. 

   Asa Akira

   Asa Akira

Ekipa 4