Elenco principal da temporada 4

1. 

   Seth MacFarlane

   Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Tom Tucker (voice)

2. 

   Alex Borstein

   Lois Griffin / Tricia Takanawa / Loretta Brown / Barbara Pewterschmidt (voice)

3. 

   Mila Kunis

   Meg Griffin (voice)

4. 

   Seth Green

   Chris Griffin (voice)

Convidados Especiais 12

1. 

   Patrick Warburton

   Joe Swanson (voice)

2. 

   Allison Janney

   Teen People Editor (voice)

3. 

   Lisa Wilhoit

   Connie D'Amico (voice)

4. 

   Adam West

   Adam West (voice)

5. 

   Camille Guaty

   Lisa (voice)

6. 

   Chace Crawford

   Luke (voice)

7. 

   Mike Henry

   John Herbert / Consuela (voice)

8. 

   David Boat

   Latino in Hardhat (voice)

9. 

   Chris Cox

   Jock / Man (voice)

10. 

    Rachael MacFarlane

    Teacher / Woman in Lab Coat (voice)

11. 

    Lori Alan

    Diane Simmons / Girl (voice)

12. 

    John G. Brennan

    Mort Goldman (voice)

Equipa técnica 2