Elenco principal da temporada 15

1. 

   Dominic West

   Jimmy McNulty

2. 

   Lance Reddick

   Cedric Daniels

3. 

   Sonja Sohn

   Kima Greggs

4. 

   Wood Harris

   Avon Barksdale

5. 

   Wendell Pierce

   Bunk Moreland

6. 

   Idris Elba

   Stringer Bell

7. 

   Deirdre Lovejoy

   Rhonda Pearlman

8. 

   Clarke Peters

   Lester Freamon

9. 

   Andre Royo

   Bubbles

10. 

    Frankie Faison

    Ervin Burrell

11. 

    John Doman

    William Rawls

12. 

    Lawrence Gilliard Jr.

    D'Angelo Barksdale

13. 

    Paul Ben-Victor

    Spiros "Vondas" Vondopoulos

14. 

    Amy Ryan

    Beatrice "Beadie" Russell

15. 

    Chris Bauer

    Frank Sobotka

Convidados Especiais 15

1. 

   Delaney Williams

   Sgt. Jay Landsman

2. 

   Pablo Schreiber

   Nick Sobotka

3. 

   Chris Ashworth

   Sergei 'Serge' Malatov

4. 

   Charley Scalies

   Thomas 'Horseface' Pakusa

5. 

   Melanie Nicholls-King

   Cheryl

6. 

   James Ransone

   Chester 'Ziggy' Sobotka

7. 

   Al Brown

   Maj. Stanislaus Valchek

8. 

   Bill Raymond

   The Greek

9. 

   Jim True-Frost

   Det. Roland 'Prez' Pryzbylewski

10. 

    Robert F. Colesberry

    Det. Ray Cole (uncredited)

11. 

    Domenick Lombardozzi

    Detective Thomas 'Herc' Hauk

12. 

    J.D. Williams

    Preston 'Bodie' Broadus

13. 

    Luray Cooper

    Nathaniel 'Nat' Coxson

14. 

    Teddy Cañez

    George 'Double G' Glekas

15. Elisabeth Noone

    Joan Sobotka

Equipa técnica 3