A former San Francisco police detective suffering from an extreme case of obsessive-compulsive disorder is called in to investigate an apparent assassination attempt of a mayoral candidate in which one of his bodyguards is killed.

With an introduction to Monk's talent, his phobia's, and need for an assistant, Monk investigates the murder of the candidate bodyguard and a political worker. He determines the candidate was not the intended target.

When a woman drives off the road to her death, her body is mysteriously found the next morning by a psychic known for fudging the truth. Monk must discover if she's telling the truth this time, or else let a murderer go free.

A police officer and friend of Stottlemeyer is framed for a crime he didn't commit involving a ferris wheel. Meanwhile Monk tries to convince Stottlemeyer to get him reinstated.

Monk is committed to an asylum, where he becomes convinced the chief psychiatrist committed a murder several years prior.

When billionaire software magnate Sidney Teal is shot dead by ex-cop Archie Modine after allegedly turning mugger and another policeman mysteriously flees the scene, Stottlemeyer calls in Monk to investigate. Meanwhile, Sharona threatens to quit (this time for sure) when her paycheck bounces, and Stottlemeyer is hounded by reporters demanding information on "Fraidy Cop."

A very tidy woman who resembles Trudy turns Monk's head while he's investigating a triple homicide. The only problem is, she's the prime suspect.

A woman is murdered during the San Francisco marathon and Monk suspects her married lover. But he was running the race, and his tracking chip says he never left.

While on vacation at a resort, Benjy claims he witnessed a murder. Monk believes him, but with no body and the cleanest crime scene Monk has ever seen, it's going to be hard to convince everybody else.

Renowned philanthropist Henry Rutherford is killed when a minor earthquake rocks the city and sends a display case falling on top of him. But when Monk examines the scene, he finds clues that suggest foul play.

When monk's favorite singer, Willie Nelson, is suspected of murdering his tour manager, Monk steps in to clear his name.

Monk's first flight proves to be harder than he anticipated when he begins to suspect that a fellow passenger murdered his wife.