Season 1 of Mr. Unlucky Has No Choice but to Kiss! premiered on April 22, 2022.

Fukuhara Kota is a university student who has unnaturally bad luck that plagues him everywhere he goes. Embarrassment at his continual comical misfortunes inhibits him from making friends.

One day he is rescued from a near-accident by Shinomiya Naoya, a good-looking fellow student with the opposite problem – supernatural good luck that brings him many friends. Shinomiya is intrigued by the unlucky Fukuhara, who asks Shinomiya to be his friend, thinking that this must surely shield him from further bad luck. He phrases his request badly but Shinomiya, thinking he is suggesting they begin dating, surprisingly agrees.