Jackie admits a patient she has treated before. As his condition worsens, Zoey questions whether Jackie did enough to help him on his previous visit. Jackie’s drug use starts to cause spontaneous nose bleeds.

Jackie and Grace begin mother-daughter tap class. Coop threatens to expose Jackie for falsifying a donor’s record. Jackie has forgotten to remove her wedding ring, and needs to get it off before meeting Eddie for a quickie.

After the confrontation with Eddie at the end of season one, it’s now a few months later. Jackie has cut ties with Eddie and is determined to dive back in and spend more time with her family. Back at All Saints, she deflects blame about the narcotic shortage and endures Sam, the altered nurse and his newfound sobriety.

Jackie covers for a hung-over O'Hara, while Eddie befriends Kevin and Dr. Coop gets hooked on microblogging.

Coop insults the biggest donor of the hospital while Jackie revisits her affair with Eddie.

Coop arranges a date for Georgia and Eddie while Jackie's daughter Grace starts therapy.

In order to keep her secret credit card a secret, Jackie sets up a P.O. box for the credit card bills. In the meantime, Mrs. Akalitus offers Eddie to come back as the hospital's pharmacist.

In order to get a phony prescription, Jackie falsifies an MRI. In the meantime the campaign's end has its effects on Coop and Eddie is back as the hospital's pharmacist.

Jackie has to confess that she used O'Hara's loan when her stash gets lost.

In the season finale, Jackie returns to All Saints where she must confront everyone.