Elenco principal da temporada 6

1. 

   Frankie Muniz

   Malcolm

2. 

   Jane Kaczmarek

   Lois

3. 

   Bryan Cranston

   Hal

4. 

   Justin Berfield

   Reese

5. 

   Erik Per Sullivan

   Dewey

6. 

   Christopher Masterson

   Francis

Convidados Especiais 19

1. 

   Alessandra Torresani

   Sara Coleman

2. Logan O'Brien

   Ronnie Demarco

3. 

   Malcolm David Kelley

   Kid

4. 

   Terry Rhoads

   Sheriff Chad

5. 

   Karen Lorre

   Vanessa

6. 

   Charlie Stewart

   Kid

7. 

   Cristine Rose

   Mrs. Demarco

8. 

   Colin Ferguson

   Deputy Brock

9. 

   Marcella Lentz-Pope

   Holly

10. 

    Jack Impellizzeri

    Deputy

11. Jonathan Jones

    Zadoc

12. Matthew Dunn

    Young Dewey

13. Cody Estes

    Young Malcolm

14. Dillon John Dailidonis

    Young Reese

15. 

    Kyle Sullivan

    Dabney Hooper

16. 

    Evan Matthew Cohen

    Lloyd

17. 

    Craig Lamar Traylor

    Stevie Kenarban

18. Kristin Quick

    Flora Mayesh

19. Daniel 'Smalls' Johnson

    Burly Guy

Equipa técnica 4