Stała obsada sezonu 6

1. 

   Frankie Muniz

   Malcolm

2. 

   Jane Kaczmarek

   Lois

3. 

   Bryan Cranston

   Hal

4. 

   Justin Berfield

   Reese

5. 

   Erik Per Sullivan

   Dewey

6. 

   Christopher Masterson

   Francis

Goście specjalni 13

1. James Rodriguez

   Jamie

2. Lukas Rodriguez

   Jamie

3. Bob Cicherillo

   Walt

4. 

   Amy Bruckner

   Zoe

5. 

   Tricia O'Kelley

   Mrs. Welsh

6. Christopher Lee Cook

   Nick

7. 

   Bill Timoney

   Uniformed Guard

8. Aaron Brumfield

   Bodybuilder #1

9. Rich Piana

   Bodybuilder #2

10. Katie Morrow

    Classmate #2

11. 

    Cameron Monaghan

    Chad

12. 

    Danny McCarthy

    Hanson

13. Derek Cox-Berg

    Classmate #1

Ekipa 6