Series Cast 52

1. 

   Charlie Sheen

   Charlie Harper (24 Episodes)

2. 

   Jon Cryer

   Alan Harper (24 Episodes)

3. 

   Angus T. Jones

   Jake Harper (24 Episodes)

4. 

   Conchata Ferrell

   Berta (24 Episodes)

5. 

   Holland Taylor

   Evelyn Harper (24 Episodes)

6. 

   Marin Hinkle

   Judith Harper (24 Episodes)

7. 

   Melanie Lynskey

   Rose (24 Episodes)

8. 

   Jeri Ryan

   Sherri (2 Episodes)

9. 

   James Edson

   Stephan 'Bobby' Wasserstein (2 Episodes)

10. 

    Nicole Forester

    Camille (1 Episode)

11. 

    Dylan Minnette

    Little Charlie (1 Episode)

12. 

    Bob Morrisey

    Dr. Little (1 Episode)

13. 

    Sean Penn

    Himself (1 Episode)

14. 

    Chloe Webb

    Trudy (1 Episode)

15. 

    Ken Jeong

    Male Nurse (1 Episode)

16. 

    Camryn Manheim

    Daisy (1 Episode)

17. 

    Suzanne Whang

    Anesthesiologist (1 Episode)

18. 

    Dayna Devon

    Shopper (uncredited) (1 Episode)

19. 

    Paget Brewster

    Jamie (1 Episode)

20. 

    Jodi Lyn O'Keefe

    Gail (1 Episode)

21. 

    Christina Chambers

    Kimberly (1 Episode)

22. 

    Orson Bean

    Norman (1 Episode)

23. 

    Brian George

    TV Narrator (1 Episode)

24. Mark Chaet

    Doctor (1 Episode)

25. 

    Kristen Miller

    Debbie (1 Episode)

26. 

    Lucy Lawless

    Pamela (1 Episode)

27. 

    Elvis Costello

    Elvis Costello (1 Episode)

28. 

    Catherine McCord

    Danielle (1 Episode)

29. 

    Harry Dean Stanton

    Himself (1 Episode)

30. 

    Alicia Coppola

    Dr. Michelle Talmadge (1 Episode)

31. 

    Ryan Stiles

    Dr. Melnick (1 Episode)

32. 

    Bobby Cooper

    Himself (1 Episode)

33. Sam Sheen

    Lisa's Daughter (1 Episode)

34. 

    Denise Richards

    Lisa (1 Episode)

35. 

    Kelley West

    Nancy (1 Episode)

36. 

    Jennifer Taylor

    Tina (1 Episode)

37. 

    Julie Dickens

    Montage Beautiful Woman (1 Episode)

38. 

    Ana Alexander

    Montage Doctor (1 Episode)

39. 

    Magdalena Holland

    Inga (1 Episode)

40. Helen Greenberg

    Nurse (1 Episode)

41. 

    David Starzyk

    Eric (1 Episode)

42. 

    Nick Toth

    TV Narrator (1 Episode)

43. Daniel Sheldon

    Little Alan (1 Episode)

44. 

    Gigi Rice

    Christine (1 Episode)

45. 

    Cynthia Preston

    Heather (1 Episode)

46. Steve Tom

    Minister (1 Episode)

47. 

    Jay Harik

    Cab Driver (1 Episode)

48. 

    John O'Brien

    Waiter (1 Episode)

49. 

    Ted Garcia

    Newscaster (1 Episode)

50. Leyna Nguyen

    Anchor (1 Episode)

51. 

    Ren Trella

    Natalie (1 Episode)

52. 

    Missi Pyle

    Miss Pasternak (1 Episode)

Series Crew 31