Jaime se disfarça em uma rede mortal de tráfico humano. Danny e Baez investigam um homicídio ligado a Darryl Reid, antigo parceiro de Danny.

Danny e Baez unem forças com a antiga parceira de Danny, Jackie Curatola, quando um serial killer reaparece. Além disso, Eddie tem que lidar com uma situação desconfortável enquanto tenta ajudar uma mulher que acusa um sargento de estupro.

Frank enfrenta a perda pessoal de seu melhor amigo, enquanto tenta encontrar a melhor forma de ajudar Tess Ross, a filha do seu melhor amigo, quando ela acaba na prisão.

Danny reencontra um adolescente problemático de um caso passado quando o jovem se encontra em perigo. Além disso, Frank enfrenta uma difícil decisão pessoal com pessoas muito próximas.

Erin é designada para liderar uma investigação federal relacionada com a corrupção nas corridas de cavalos. Jamie investiga uma operação de tráfico de drogas envolvendo gangues rivais; Danny e Baez investigam uma série de ataques em Little Vietnam com a ajuda de um rosto bem conhecido.

Danny e Baez investigam um homicídio envolvendo vodu. Eddie e um colega se unem à Capitã McNichols para investigar o processo seletivo de uma escola prestigiosa.

Jamie investiga golpistas que fraudam idosos; Danny e Baez investigam uma série de mortes misteriosas em um hospital; Anthony trabalha para derrubar um advogado corrupto.

Danny and Baez are on edge when a serial killer, who once targeted Baez and her daughter, is released early from prison. Jamie and Anthony team up on an investigation involving one of Anthony's criminal informants, his ex-wife’s brother. Eddie clashes with Captain McNichols over a sergeant who keeps downgrading her cases. Frank is upset when Abigail goes behind his back regarding a professional favor for her husband.

Danny gets involved when Sean becomes the latest victim in a series of robberies on his college campus. Erin grows suspicious of an overworked attorney who she believes isn't acting in his client's best interest.

Danny and Gormley race to find a detective who is dangerously determined to uncover how a rapist he arrested is back on the streets.

The Reagans' professional lives converge when an allegation of jury tampering against Erin intertwines with Danny and Baez's homicide case and Eddie's bond to a child murder witness. Frank clashes with his friend and confidant Archbishop Kearns over the death penalty. When Jamie's car is stolen, he joins forces with his nephew to recover it.

Danny joins forces with British investigator Christopher Granger to pursue a deadly international fugitive. Erin faces pressure from her boss to secure an indictment against an officer.

Frank intervenes when tensions rise between Mayor Chase and the Fire Commissioner. Erin is blindsided when Henry agrees to testify for the defense in a case she is prosecuting. Danny and Baez investigate when human remains are discovered in a storage unit. Eddie and her partner navigate a complicated arrest when their criminal offender is scheduled to donate his kidney.

Danny and Baez scrutinize an art gallery suspected of selling counterfeit pieces after a detective investigating the establishment is murdered.

Danny and his nephew investigate the homicide of a delivery driver who may have been connected to an illegal narcotics ring. Eddie is determined to save the job of a probationary police officer who may be fired for responding to a crime. Frank faces a hard decision when he discovers Gormley is non-compliant with NYPD residency requirements. Erin clashes with her boss when a seemingly rehabilitated criminal from an old case becomes the subject of an armed robbery investigation.

Danny and Baez investigate the death of a rising MMA fighter. Eddie and Jamie race to find Badillo, whose job is on the line after he's caught smoking weed.

Danny and Baez investigate when a star student is found dead in her dorm. Eddie and Badillo try to help a man whose apartment has been taken over by a squatter — who also happens to be Jamie's confidential informant. Frank suspects the Governor has an agenda when he comes to him with a proposal. Erin oversteps when she tries to play matchmaker for Anthony.

It's all hands on deck for the Reagan family, as they race to stop deadly mayhem in the city when the gangs of New York unite to demand amnesty and the release of their imprisoned members and those awaiting trial.