Elenco principal da temporada 6

1. 

   Alex O'Loughlin

   Steve McGarrett

2. 

   Scott Caan

   Danny 'Danno' Williams

3. 

   Grace Park

   Kono Kalakaua

4. 

   Daniel Dae Kim

   Chin Ho Kelly

5. 

   Masi Oka

   Dr. Max Bergman

6. 

   Michelle Borth

   Catherine Rollins

Convidados Especiais 12

1. 

   Chi McBride

   Lou Grover

2. 

   Brian Yang

   Charlie Fong

3. 

   Floriana Lima

   Allison Hutchins

4. 

   Taryn Manning

   Mary Ann McGarrett

5. 

   Xzibit

   Jason Dekker

6. Antonio Bustamante Jr.

   HPD Narcotics Officer

7. 

   Daryl Hannah

   Cherie Tranton

8. 

   Colby French

   ATF Special Agent Blake Kennedy

9. 

   Brian Tee

   Hideaki Kuroda

10. Christie Burson

    Linda Davies

11. 

    Westley LeClay

    Matt Hutchins

12. Cathy Foy

    Nani

Equipa técnica 2