Monroe goes head to head with his new boss when he elects to operate on a patient with a deadly vascular anomaly. Meanwhile, Jenny Bremner returns to St. Matthew's from maternity leave to find the hospital changed - and her power diminished.

The neurosurgeon finds himself having to choose between trainees Springer and Wilson, who are both equally deserving of a place on his team, while cracks begin to show in Bremner and Shepherd's relationship. Monroe's patients include a woman with an aggressive brain tumour, which presents him with one of the most challenging cases of his career.

Monroe is still reeling from the result of Lynn Monkford surgery. He makes his decision on who to promote to registrar. Shepard is left to deal with what he did the previous night, he and Bremner decide to try counselling to repair their relationship.

Monroe's confidence has returned, with his ex-wife happily involved with her new boyfriend Dave, he decides to take new colleague Lizzie out on a date Shepard and Bremner are doing their best to play happy families, but the underlying issues are still festering.

Shepherd has moved into Monroes. Springer has some legal issues.

Monroe has informed Bremner after Shepards activites. Witney appears to have decided that its time to leave St Matthew’s. Monroe decides to throw a stag party for his son Nick. Meanwhile at the hospital Springer is introducting Jacob Namobu, a young medical student to neurosurgery. Things don't go to plan when there is a large road traffic accident. This night the truth will be revealed, someone will die, and someone will resign.