Significant Others is an American sitcom that aired on Bravo for two seasons in 2004. Following four couples from various backgrounds in and out of therapy, it focused on issues of adultery, parenthood, impending parenthood, and the chore of behaving like an adult. Adopting the tone of many British comedies, it was almost entirely ad-libbed, without a laugh track, and put the viewer in the position of therapist, as the couples addressed the camera directly during the therapy sessions featured during each episode.

Produced by NBC, it was distributed by Bravo, the cable network on which it aired until its last episode on December 19, 2004. While it primarily flew under the radar during its short run, it was heralded by many critics for its originality, dark humor, and fresh take on the pains of wedded "bliss." Its entire two-season, twelve episode run was released on DVD by Shout Factory on February 14, 2006.