Jenny Lee start her midwife career at Nonnatus House in London. She is surprised to find that it is a nursing convent and not a hospital. Her first case is a woman pregnant for the 25th time!

A new girl arrives Nonnatus House and finds it hard to earn the respect of Sister Evangelina. Jenny sees an unfamiliar darker side of life following an encounter with a runaway.

When Chummy's imperious mother visits and disapproves of Peter Noakes, Chummy defies her mother and has her wedding on her own terms. Senile Sister Monica Joan is arrested for shoplifting.

Dr Turner and Nurse Crane must deal with an alarming outbreak of diphtheria. Fred finds an abandoned baby in a dustbin, and the team must help locate its mother.

Sister Julienne decides it is time to take matters in hand when a letter arrives from the council saying that it will cut funding to Nonnatus House and no longer pay for the accommodation, and goes to see Violet at one of her open sessions as a local councillor.

Sister Julienne and Dr Turner clash over whether to provide a private care service, and a distressing birth raises fears of another Thalidomide case.

It’s July 1966, and Britain is in the grip of World Cup fever. New pupil midwife Nancy makes quite an impact.

Nonnatus House struggles to come to terms with Nancy’s revelation. With Sister Julienne taking her annual leave at the Mother House, Sister Hilda relishes the chance to cover and impress with her leadership.

While attending an expectant mother, Sister Frances and Trixie are appalled to learn that Poplar’s housing crisis is worsening, leaving the Nonnatus team vowing to fight for change.

It’s a poignant time for the Turner family as Timothy readies to leave for medical school in Edinburgh and Cyril receives news from home, prompting him and Lucille to consider their own future.

Meanwhile, a very special baby is born, who causes a rift in a close-knit family and leads many people to count their blessings.

Demolition work in Poplar uncovers a long-buried secret that leads to a testing and emotional case for the team. Sister Julienne takes on a sensitive delivery.

Shelagh organises a special celebration to mark 100 years since the Order first arrived in Poplar - although Sister Hilda feels that she should have been in charge of the festivities. Nancy tackles the plight of meths drinkers living rough in Poplar, and Nurse Crane treats a young singer who is torn between two very different futures.

Trixie has been assigned to a complicated case involving a crane driver who was injured in a workplace accident and is now paraplegic. Meanwhile, Nancy and Sister Frances give a talk on the facts of life at a primary school, and Lucille's attendance at a straightforward delivery takes a distressing turn. Shelagh decides to organise a jumble sale to raise money to fix some broken playground equipment in the park. When Sister Julienne finds a suspicious item, chaos ensue

Nonnatus House faces its darkest day after a tragic incident in the heart of Poplar. As the community rallies together, the team must overcome personal anguish to help the injured.

The Turners support a family still suffering the devastating effects of thalidomide, Miss Higgins is involved in an unexpected delivery, and the community stages a talent show.

April 1968. Racial tensions cast a shadow over Poplar, Nancy’s eyes are opened when she supports a dying woman, and Nonnatus House welcomes a new sister.

A pregnant mother with a chronic heart condition falls unwell, Nancy grows suspicious of a young father’s erratic behaviour, and Matthew prepares for a visit from his father.

Dr Turner experiences the biggest test of his career, while Trixie’s approaching nuptials cause stress levels to escalate. Sister Julienne hatches a plan to save Nonnatus House.

As Poplar prepares for Christmas, Sister Monica Joan fears this could be her last. Dr Turner and the midwives deal with a complicated multiple birth, and Cyril helps a war veteran.

Sister Julienne cares for an expectant mother who has cerebral palsy. Nonnatus House kicks off its new midwifery training scheme with the arrival of four new pupil midwives.