Sister Frances is at a loss when she cares for diabetic and recovering cancer patient Albert Calthorpe whose fiercely independent wife Grace refuses to accept further help, despite caring for her husband, her elderly mother and her pregnant daughter.

Sister Frances finds herself in a tricky situation when a pregnant woman confides in her. Sister Julienne’s new venture hits a stumbling block.

Shelagh organises a special celebration to mark 100 years since the Order first arrived in Poplar - although Sister Hilda feels that she should have been in charge of the festivities. Nancy tackles the plight of meths drinkers living rough in Poplar, and Nurse Crane treats a young singer who is torn between two very different futures.