Nickelodeon Splat! is a television block on Nickelodeon. It aired live every weekday in the summer of 2004, during commercial breaks between Nickelodeon shows on the early evening programming block. It was a game show, with teams divided into three colors. The teams, made up of audience members and park guests age 7 to 16 taken from the Universal Studios Florida theme park, would have to perform silly humorous tasks to earn prizes. At the end of each show one team would win, and the team along with its captain and respective portion of the studio audience would be blasted with the network's trademark slime. An ongoing score was also kept, and at the end of the series, the yellow team had won.

The show was canceled in October 2004. It was the final program to be taped at Nickelodeon Studios, as the studio closed less than a year after the final taping.