Season 1 of Mark Twain Prize premiered on January 20, 1999.

Season 2 of Mark Twain Prize premiered on January 12, 2000.

Season 3 of Mark Twain Prize premiered on February 28, 2001.

Season 4 of Mark Twain Prize premiered on November 21, 2001.

Season 5 of Mark Twain Prize premiered on November 13, 2002.

Season 6 of Mark Twain Prize premiered on November 26, 2003.

Season 7 of Mark Twain Prize premiered on March 2, 2005.

Season 8 of Mark Twain Prize premiered on November 9, 2005.

Season 9 of Mark Twain Prize premiered on November 20, 2006.

Season 10 of Mark Twain Prize premiered on November 12, 2007.

Season 11 of Mark Twain Prize premiered on February 4, 2009.

Season 12 of Mark Twain Prize premiered on November 4, 2009.

Season 13 of Mark Twain Prize premiered on November 14, 2010.

Season 14 of Mark Twain Prize premiered on October 31, 2011.

Season 15 of Mark Twain Prize premiered on October 30, 2012.

Season 16 of Mark Twain Prize premiered on November 24, 2013.

Season 17 of Mark Twain Prize premiered on November 23, 2014.

Season 18 of Mark Twain Prize premiered on November 23, 2015.

Season 19 of Mark Twain Prize premiered on October 28, 2016.

Season 20 of Mark Twain Prize premiered on November 20, 2017.

Season 21 of Mark Twain Prize premiered on November 19, 2018.

Season 22 of Mark Twain Prize premiered on January 7, 2020.

Season 23 of Mark Twain Prize premiered on June 21, 2022.

Season 24 of Mark Twain Prize premiered on March 26, 2023.

Season 25 of Mark Twain Prize premiered on May 11, 2024.