In the Season 6 premiere, host Anthony Melchiorri challenges himself and his team when they hit the road in a tricked-out RV to help three struggling hotels on a stretch of Route 66 in Arizona. Included: Guidance is offered to the owners of a once-thriving "luxury" inn, a former bordello on the National Registry of Historic Places and a camping and trailer park.

Bed bugs need to be exterminated from the 40-room Country Barn Motel in Nashua, N.H., where Anthony encounters three owners who argue and aren't receptive to change.

Anthony visits Orlando, FL, where he discovers that the 350-room ANice Inn & Suites is anything but nice. After finding killer bees, bedbugs, mold & feral cats, can Anthony force an owner to invest in fixing all the issues?

Anthony travels to Cedar City, UT, to help the owners of the Stratford Court Hotel. Upon arrival, he discovers that they are already busy renovating the lobby... but haven't closed the hotel.

Anthony is in Hershey, PA, mecca for thrill-riders & chocoholics. But the GM of the struggling Simmons Motel has a more serious addiction, so they hold an intervention to help him see he's hurting the business and his family.

Anthony is in Niagara Falls, NY, at the 55-room Waldorf Niagara Hotel. The owner's frugality has affected the hotel, from soaked carpets & bed bugs to fire safety issues. Can Anthony help this hotel before new ones open nearby?

Anthony travels to the Las Olas Resort in Panama and discovers that it's in the middle of nowhere and the cabs are unreliable. When he finally gets there, he finds bathrooms covered in an iron film, a bland pool area, and a restaurant with too many menu items for its own good.

The 24-room Sea Shell Motel in Virginia Beach is losing money. When Anthony arrives, he finds an older owner who doesn't want to change his ways and refuses to give refunds for poor rooms and lousy customer service. The owner's daughter and son-in-law have a plan to take over, but the other daughter has her own ideas.

The Capital Plaza Hotel in Frankfort, KY, has finances that are out of control, a maintenance director that is more interested in a microbrewery than basic maintenance, and water pans in the ceiling.

Anthony is called in to help the Grant Hills Motel in Galena, IL. However, he soon discovers that the motel's main issue isn't the poorly maintained rooms but the feuding sisters who run the place.

Anthony deals with the Lancer Motel, a 59-room blight in Myrtle Beach, South Carolina, which suffers from disorganized management, bedbugs, and a staff that are paid far below minimum wage.

At the 120-room Brookside Resort in Gatlinburg, TN, Anthony has to deal with a manager who doesn't like to confront guests, overworked housekeepers, and filthy rooms.

Anthony travels to Bangor, Maine, to help out the Charles Inn. Not only is the hotel losing money, but it has a noisy bar attached to the lobby and the manager insists that he owns 50% of the bar.