Fiona is deeply missing Ed and thinks that The Clinic is falling apart without him. In her attempts to save The Clinic she only manages to make matters worse. Cathy too is feeling the aftermath of Ed's departure and is unable to cope with the daily business.

Brendan's inheritance of his Nan's house worth 2.75 million euro has just become official. The other staff in The Clinic question Brendan on what he would like to do with this money. Brendan is happy with his life and has no intention of selling his beloved Nan's house. Everybody has an ambition except for him and he tries to live his ambition through Clodagh.

Patrick is lonely and everything around him is further illustrating how alone he is. Through a chance encounter with an old acquaintance, he learns that his ex-wife Lisa is in town. They arrange to meet. Lisa hasn't seen him sober in a long time and is surprised by this new man. They get on great, the sparks are flying and their relationship takes a new turn.

Clodagh gets some shocking news, her father had an affair and she was the product of it. Daisy takes a fancy to Brendan's replacement, Will Cafferty. Cathy & Dan's relationship develops further.

Mr O'Callaghan's demise is revealed as he plummets from the high of the nomination for his Presidency to the depths of despair when he loses out. He is unable to take any more or to reach out to anybody, most notably Cathy

Richard is struggling to deal with his wife Annie's illness while trying to keep his home and work life separate. His daughter Flossie is devastated when she discovers that she could have the Huntington's gene. Trying to pretend that everything is okay and not accepting help has not worked, Richard finally comes to the realisation that he has to face up to his wife's illness.

Daisy has fallen hook, line and sinker for Will, along with his drinking, drugs and fast living. They spend the night together in Cathy's flat. Will refuses to get up and come to work the next day, much to Daisy's dismay.

Dan is terrified when he realises he could be caught out for dating both Cathy and Sinéad and tries to find a way to prevent them meeting. Dan is thwarted when Sinéad meets Cathy. He tries to talk his way out of it by telling Cathy it was her idea to have a no strings attached relationship and as soon as they started to get serious he finished with Sinéad.

Alex is shaken when he bumps into an old friend at a club, who calls him Chris. Alex tells the guy to get lost claiming he doesn't know who he is and walks off with Sam in tow. Alex and Sam argue later at home. Sam thinks Alex has been picking up other men calling himself by a different name.