Cathy continues to lie in a coma after being run over by Niall Boylan unaware that she lost her cherished baby girl - Rachel - in the accident. Liam's son Ian is in trouble yet again and gets expelled from school and Liam has no choice but to put him into a fee paying school. Daisy returns home with Conor to be at Cathy's bedside and is there when Cathy suffers a brain haemorrhage and dies.

Dan's grief over Cathy's death is overshadowed by hearing that Niall Boylan will escape relatively free from a serious conviction. Dan's solicitor warns Dan to stay away from Niall. Meanwhile, new locum Dr Grace Sefate makes an impact on her first day when her belongings turn up before her. This unusual entrance immediately gives Grace an air of intrigue but she immediately asserts herself as a capable and dedicated doctor. Lorcan starts to struggle with his illness, now that he is on a harsh course of anti-retroviral medication for his HIV and this sees him becoming ...

St. Matthew's Hospital Director Michael Kinsella is keen for Julia to take over the job but she declines and tells him she is happy at the Clarence Street Clinic but will she regret her decision when long standing patient of hers Elayne Sheridan discovers she is pregnant for the fourth time and places Julia in an unenviable dilemma. Meanwhiile, Dan continues his thirst for revenge on Niall Boylan through his wife, Aideen and discovers her love of art. Clodagh agrees to help out on the night clinic and the methadone bus and is moved by Lorcan's dedication to his ...

Grace tells Ruairi about her missing sister Jasmine when he finds one of her flyer's on the photocopier. Lorcan asks Dr Kent about getting involved with someone given his HIV status. Keelin notices that a young client's fitness levels have gone through the roof and later he suffers a heart attack brought on by his use of illegal steroids. Ian and Liam agree a truce but Liam's dependence on Rocusin tablets makes him jump to incorrect conclusions about Ian later after he sees Ian's old buddies Phil and Martin outside their house.

Ronan and Keelin's lives are turned upside down when a senseless attack on Ronan by one of Ian's friends leaves him potentially paralysed. Meanwhile, Liam's addiction begins to get worse and cracks begin to appear in Daisy and Conor's relationship as Daisy struggles to juggle her work with her home life. Elsewhere, Cara struggles with what she did to Hope and Kieran.

Liam continues taking Rocusin, and even steals a prescription from one of Grace's patients. After giving wrong medication to another patient, Liam blames Grace and convinces the patient to back up his story. Julia takes Liam's side in the matter. It takes Alice to recognize that it is Liam that is at fault and she goes to Lorcan about his behaviour. After being confronted, Liam admits to his drug abuse and it leaves Julia with no option but to suspend him from work. Elsewhere, Aideen doesn't turn up at the airport and later tells Dan to leave her alone. Later Dan is ...

Alice secures a temporary role as the nurse in the clinic, and is keen to celebrate with Dan. Annie Ward brings her ex-boyfriend, Dave, to the night clinic in an effort to wean him off heroin with disastrous consequences.

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Dan and Daisy face Niall Boylan in court but later find out that he has been killed. After Alice lets slip about Lorcan's HIV status Dan confronts him. Later, Dan is arrested for Niall Boylan's murder.