欢迎来到摇摆不定的六十年代。威廉·马斯特斯博士和弗吉尼亚·约翰逊博士因发表有争议的研究而成为聚光灯下的焦点，他们发现自己不太可能成为性革命的领导者。但随着新发现的名声和压力的增加，他们的关系变得扭曲和纠结，使这对夫妇处于甚至他们可能无法处理的位置。

Welcome to the swinging sixties. Thrust into the spotlight by the publication of their controversial study, Dr. William Masters and Virginia Johnson find themselves the unlikely leaders of the sexual revolution. But as newfound fame and pressures mount, their relationship becomes twisted and tangled – putting the couple in a position that even they might not be able to handle.

En 1966, l'étude de Bill et Virginia, rendue publique, amorce une révolution dans les moeurs. Le mariage de Bill est mis à rude épreuve.

빌과 버지니아의 책이 출판된 뒤 찬사, 논란, 원치 않는 관심을 불러 일으키고, 장면이 1965년으로 넘어간다.

Bizi 1965'e götürerek başlayan üçüncü sezonda, Bill ve Virginia'nın kitabının yayınlanması; övgü, tartışma ve istenmeyen bir ilgi yaratır.