The Brain Game is a weekly quiz bowl show for high school students that airs on NBC-affiliate WTHR-13 in Indianapolis, Indiana. It is currently broadcast at 7 pm on Saturdays, and the host is WTHR lead meteorologist Chris Wright. It is sponsored by Westfield Insurance, which also sponsors four other high school quiz shows. The show is filmed at the WTHR studios on Meridian Street in Indianapolis. Since 2008 Brain Game has been filmed in HD.

Chris Wright has hosted the Brain Game since 2000, and Bob Gregory did so for 28 years from the show's start in 1972 until 2000. Until 2008 it was filmed at the Fairbanks Center at Butler University.

The Brain Game was nominated for a Regional Emmy in 2001 for best On Camera Talent - Non News, in 2003 for best Children/Youth Program - Regularly Scheduled, in 2004 for best Children/Youth Program - Regularly Scheduled, and in 2007 for best Children/Youth Program.