Season 1 of Smile, Mom premiered on November 6, 2010.

A drama about three women and their families. Jo Bok Hee is dealt with a huge blow when her successful daughter, Shin Dal Rae, is diagnosed with an incurable disease. Kang Shin Young is betrayed when her husband, Shin Muh Roo, continues to meet his first love, Hwang Bo Mi. When he enters the race for congressman, she runs against him.