Stała obsada sezonu 6

1. 

   Melissa Benoist

   Kara Danvers / Supergirl / Kara Zor-El

2. 

   Chyler Leigh

   Alex Danvers / Sentinel

3. 

   David Harewood

   J'onn J'onzz / Martian Manhunter

4. 

   Jeremy Jordan

   Winn Schott

5. 

   Calista Flockhart

   Cat Grant

6. 

   Mehcad Brooks

   James 'Jimmy' Olsen / Guardian

Goście specjalni 13

1. 

   Jenna Dewan

   Lucy Lane

2. 

   Chris Vance

   Non

3. 

   Italia Ricci

   Siobhan Smythe

4. 

   Laura Vandervoort

   Indigo

5. Patrick O'Connell

   General Mathers

6. 

   Malina Weissman

   Young Kara Zor-El

7. Kelly Chavers

   Girlfriend

8. 

   Michael Hanson

   Guy #2

9. 

   Nick Jaine

   Guy #1

10. Carly Nykanen

    Woman

11. 

    Ruben Vernier

    Boyfriend

12. 

    Jay Jackson

    News Anchor

13. 

    Briana Venskus

    Agent Susan Vasquez

Ekipa 5