Elenco Principal da Temporada 10

1. 

   Melissa Benoist

   Kara Danvers / Supergirl / Kara Zor-El

2. 

   Chyler Leigh

   Alex Danvers / Sentinel

3. 

   David Harewood

   J'onn J'onzz / Martian Manhunter

4. 

   Katie McGrath

   Lena Luthor

5. 

   Jesse Rath

   Querl 'Brainy' Dox / Brainiac-5

6. 

   Nicole Maines

   Nia Nal / Dreamer

7. 

   Azie Tesfai

   Kelly Olsen / Guardian

8. 

   Julie Gonzalo

   Andrea Rojas / Acrata

9. 

   Staz Nair

   William Dey

10. 

    Andrea Brooks

    Eve Tessmacher / Hope

Convidados Especiais 10

1. 

   Mitch Pileggi

   Rama Khan

2. 

   Meaghan Rath

   Querl Dox / Brainiac-5

3. 

   Michelle Christa Smith

   Sela

4. 

   Cara Buono

   Gamemnae / Gemma Cooper

5. 

   Lynda Boyd

   Eve Tessmacher's Mother

6. 

   Sharon Leal

   M'gann M'orzz

7. 

   Everett Andres

   Young Boy

8. 

   Guy Christie

   Passerby

9. 

   Jon Cryer

   Lex Luthor

10. 

    Brenda Strong

    Lillian Luthor

Equipa Técnica 5