A monster is moving toward City Z, one that has been created by the mysterious organization known as The House of Evolution. Genos, a young cyborg, attempts to stop it, but gets in over his head before Saitama happens along.

Saitama and Genos glean information about The House of Evolution and its founder Dr. Genus, a scientist with dangerous ideas on artificial human evolution. Meanwhile, Dr. Genus learns of Saitama’s amazing strength and has plans of his own for One-Punch Man.

A group of battlesuit-clad terrorists called “The Paradisers” appears in City F, led by an enormous man known as Hammerhead. Calling for the redistribution of wealth, the group targets the fat-cat Zeniru, who in turn dispatches his bodyguard to defeat them. Unfortunately, Saitama is on the same errand.

A pack of monsters calling themselves the “Clan of the Seafolk” arrive on the shores of City J intent on invading the land. When the hero sent to fight them is defeated easily by the Deep Sea King himself, Saitama and Genos head for the city to help.

As the battle with the Deep Sea King reaches its climax, more heroes fall to the aquatic despot’s brutal attacks. Which of them has what it takes to be a true hero?

As a colossal spaceship floats in the skies above City A, a member of its monstrous crew battles on the ground against a group of S Class heroes. Despite their powers, they can’t seem to finish it off. Meanwhile, Saitama has boarded the enemy ship on his own.