Andie is undateable– thanks to her older brother Alec, the most popular guy in high school, who makes sure no guy comes near her. Fortunately, Andie has her three best friends to help her shake the little sister stigma: Dakota, the gay best friend who is more than confident in his own sexuality; Imogen the innocent, fresh-out-of-home-school wallflower; and Courtney, Alec’s girlfriend and last year’s homecoming queen, who can’t let go of her high school days. These four very different personalities help each other navigate the hormone-induced, angst-filled sea of high school.

Buscando explorar su lado salvaje, cuatro completos extraños se encuentran en una lujosa mansión. Durante las siguientes 24 horas, ocurre todo en tanto que los sexies solteros dan rienda suelta a sus inhibiciones y forman parte de la aventura erótica de sus vidas.

A série conta a história de Andie, uma garota de 16 anos que não consegue namorar nenhum garoto por causa do irmão super protetor (o cara mais popular da escola).

Com a ajuda de seus 3 amigos ela espera mudar isso.