Suburban mother and wife Tara Gregson does her best to lead a normal life while dealing with multiple personalities that include a spirited teenager called "T," a Vietnam vet named "Buck," and the perennial 1950's-style housewife, "Alice."

Tara feels like a failure as a mother when she is unable to counsel her children about school and sex, so she turns to her perfect-homemaker personality "Alice" for help.

When Tara and Max can’t connect in the bedroom, Tara worries Max may be more interested in her alters than her. After gaining reassurance from her therapist Dr. Ocean,Tara plans a “sex date” with Max to get them back on track. Tara’s sister Charmaine recommends she meet her new boss for a potential mural project. As Tara prepares for her “sex date” with Max, the pressure becomes too much and she becomes “Buck.” That night, “Buck” doles out advice on women and Max ends up male-bonding with his own wife.

Charmaine has decided to get her breasts re-done and has asked Tara to be her caretaker while she recovers. Kate gives Marshall Love advice, telling him to play hard to get with Jason. When Charmaine wakes after her surgery, she is surprised to see “Buck” at her bedside, not Tara. While “Buck” takes care of Charmaine, she comes to appreciate him in a way she never has before.

With Max and Dr. Holden’s help, Tara meets face-to-face with an important person from her past. This meeting, while difficult, leaves Tara feeling conciliatory and expansive. Marshall finally reconciles with Tara and gives her his full support. The family, now reunited for the first time since Tara checked into the hospital, decides to partake in a family tradition – bowling but as Tara looks around at her family, she realizes she’s not who she is in spite of her alters, but BECAUSE of them.

Season two opens with a bang as the Gregsons' neighbor commits suicide and the family unexpectedly is given responsibility of the house. Now well and dissociation-free for several months, Tara sets out to make new friends with Max's help. Marshall struggles to fit in at school while Kate lands a new job. Nick pops the question to Charmaine

Tara and Lynda make preparations for their art show. Kate sets up a new business, while Lionel and Marshall's friendship deepens. In the meantime, Charmaine struggles trying to balance Neil and Nick.

On the day of Charmaine and Nick's wedding, long-held secrets come to light, while Kate and Marshall accidentally make a discovery of consequence.

Max is worried when Tara returns to college to finish her college degree. Meanwhile, Charmaine with a baby on the way is avoiding a commitment to Neil, Kate tries to figure out a plan for her future and Marshall and Lionel sign up for a filmmaking class.