Season two opens with a bang as the Gregsons' neighbor commits suicide and the family unexpectedly is given responsibility of the house. Now well and dissociation-free for several months, Tara sets out to make new friends with Max's help. Marshall struggles to fit in at school while Kate lands a new job. Nick pops the question to Charmaine

Tara realizes her alternate personalities are emerging again, but keeps it a secret. Newly engaged Charmaine asks to move in with Tara and her family. Max decides to take on a new project by buying the neighbor’s house to flip it. Kate meets a mysterious older woman, Lynda (Viola Davis), while Marshall begins a new relationship… with a girl

Tara and Charmaine pay a woman who appeared in Tara's memories a visit, while Kate tries to change herself for her new and much older boyfriend.

On the day of Charmaine and Nick's wedding, long-held secrets come to light, while Kate and Marshall accidentally make a discovery of consequence.

Max is worried when Tara returns to college to finish her college degree. Meanwhile, Charmaine with a baby on the way is avoiding a commitment to Neil, Kate tries to figure out a plan for her future and Marshall and Lionel sign up for a filmmaking class.

Her psychology professor humiliates Tara when she transitions in his class. Meanwhile, Kate considers giving English lessons in Japan and Max gets a business offer.

The stress of juggling school and Charmaine's baby shower causes Tara to transition, with negative consequences for Charmaine. To sell the family business, Max must get the approval of his eccentric mother. Kate meets a flight attendant who inspires a new idea about her future.

A new alter comes to light that put Charmaine's new baby at risk. Soon later, Alice visits Dr. Hattaras and intrigues him in Tara's case again. Kate, Max and Marshall fly to New York where they get to meet Kate's new friend Evan and his son.

When Bryce takes over, Tara's new alter threatens to destroy the whole family. When Tara's other alters disappear one by one, Max decides to fight off Bryce before it's too late for Tara.

Tara re-emerges but the task now is to repair broken family relationships, particularly with Marshall who is fed up with it all. Rather than go into a local mental health facility, she decides to follow Dr. Hatteras' advice and see a specialist in Boston. Neil and Charmaine are moving to Houston and offer to take Marshall with them. Kate receives an offer to move to St. Louis. As a new family dynamic emerges, everyone contemplates and wonders what the future may hold.