Il y a 20 ans, Masayoshi était membre d'un groupe de cambrioleurs nommé "TAKE FIVE". Son père était aussi dans le groupe. Maintenant, il mène une vie ordinaire et honnête, travaillant comme professeur de psychologie à l'université. Un jour, il reçoit une photo d'un tableau de Léonard de Vinci d'une mystérieuse sans-abri. Elle indique à Masayoshi que le tableau est entreposé dans l'entrepôt de sécurité de Toto Bank comme si elle connaissait le passé de voleur de Masayoshi.

Masayoshi curieux de savoir si le tableau est vraiment stocké à Toto Bank, reforme "TAKE FIVE". Le groupe décide de travailler dans le cadre où ils ne voleront que des objets de grande valeur à des personnes malfaisantes.

Vinte anos atrás, o lendário grupo de ladrões "Take Five" esteve aparentemente envolvido num acidente que causou a morte de um policial. Por esta razão o grupo dissolveu-se e cada um continuou sua vida deixando o mundo do roubo. Homura Masayoshi era um dos integrantes e atualmente dá aulas de Psicologia numa boa universidade. Um dia encontrou-se a com uma estranha mulher que lhe mostrou uma foto do retrato de Lucrezia, pintado por Leonardo da Vinci, lhe convidando a entrar de novo nesse mundo que deixou para trás. A partir daí, de uma forma ou outra, ressuscitará "Take Five" sem saber ainda qual é o verdadeiro significado desse retrato nem a identidade dessa misteriosa mulher.

曾几何时，绰号为“TAKE FIVE”的五人盗贼团伙纵横江湖。他们秉承“以盗救人”的宗旨，将从坏人那里偷来钱财的返回受害者，行侠仗义，备受民众爱戴。然而在某次行动中一名警察遇害，由此终结了TAKE FIVE的命运。数年过后，达·芬奇的名作《卢克雷奇娅肖像》将TAKE FIVE当年的伙伴帆村正义（唐泽寿明饰）、火冈均（入江甚仪饰）、南真一（六角精儿饰）集结在一起，加上某银行安保设计师出身的新生代盗贼新美晴登（松坂桃李饰），以及性格极度认真深不可测的警官岩月櫂（稻垣吾郎饰），全新的Take Five再度结成。对当年事件耿耿于怀的帆村，命运般邂逅嫉恶如仇的女警（松雪泰子饰），宿命因缘将黑白双方紧紧缠绕在一起

Up till 20 years ago, together with his father and 3 other people, Homura Masayoshi was part of the legendary group of thieves that called themselves 「TAKE FIVE」. This group stole from the rich who had acquired their wealth through immoral means. Due to an incident, Masayoshi decided to retire from the group, and settled into his life as a professor of Psychology at a reputable university. One day, he runs into a mysterious homeless woman, who passes him a picture of a Leonardo Da Vinci's painting, which prompts him to re-enter the world of thievery and resurrect 「TAKE FIVE」.

Sasahara Rui joined the Burglary Division in the footsteps of her father, who had died in an accident involving a burglary heist. She wows to take down 「TAKE FIVE」 and stop them from stealing again.

What was the real reason for the disbanding of 「TAKE FIVE」 20 years ago? Who is the mysterious homeless woman and what is the significance of the Da Vinci picture she had given to Masayoshi? How did Rui's father really died?