Max and Luna make friends in an unexpected place as Max struggles with the realities of being a single father. Meanwhile, Kapoor takes a big step in order to help his family.

Sharpe has an important realization that will affect her career. Meanwhile, Max and Reynolds take on uncharted waters when a young patient comes to New Amsterdam with symptoms of a heart attack.

Max races against the clock to rearrange the budget when faced with employees going unpaid, while Kapoor is presented with a device that's the future of medicine. Meanwhile, Iggy goes against the norms to prove a diagnosis and Bloom gets an unexpected visitor.

When tasked with turning the opioid epidemic around, Max shuts down the ED and proposes a massive change. Meanwhile, Sharpe goes great lengths to prove a point.

Max, Bloom and Reynolds frantically recount a patient's past encounter that could throw them into a massive lawsuit. Meanwhile, Iggy confronts a local middle school about its teaching policies, and Kapoor lets his superstitions take over.

When multiple patients throughout the hospital begin to show similar, alarming symptoms, Sharpe and Bloom scramble to figure out the root of the issue. Iggy tries to create peace for a divorced couple in a dangerous situation and Kapoor experiences a flirtatious encounter. Meanwhile, Max meets a child with a rare muscular disease and desperately tries to get him into the only clinical trial in the country that could extend his life.