Max works to find a new normal three months after the accident and the birth of his daughter. Kapoor grapples with the stigma of aging. Iggy has a successful day that inspires a life-changing idea. Reynolds deals with an unreliable new intern.

Max invokes a hospital-wide census in effort to get to know the staff of New Amsterdam on a deeper level. Reynolds takes a leap of faith that lands him in hot water, and Dr. Castro extends her treatment plan to more patients in the hospital.

Max takes a chance on a new assistant and goes toe-to-toe with the board on a new plan; Iggy struggles to figure out what is causing a unit-wide illness; Kapoor receives some shocking news.

When Iggy and Kapoor discover a patient might be suffering from lead poisoning, they are forced to take on the city. Meanwhile, Max's unsolicited attempts to help a patient backfires.

When Sharpe has a case that hits close to home, she and Max team up to make things right for the patient. Meanwhile, Iggy and Bloom are forced to make a tough call on a unique situation.

When a group of women on a retreat end up in the ED, Max gets some troubling information that could put a patient in jeopardy. Meanwhile, Sharpe and Kapoor work together to mend fences between two feuding sisters.

When Kapoor introduces a patient to Iggy's PTSD group, a creative treatment plan causes turmoil. Sharpe discovers a long-kept secret regarding a patient.

Sharpe lands in hot water when she goes out on a limb for a patient. Max's grief comes to a head. Bloom takes a major step in her recovery.

When an inmate comes in with an entirely preventable illness, Max, Sharpe, and Iggy head directly to the source - Rikers Island. Meanwhile, Bloom struggles with her recovery, and Reynolds gets news that could change his life.

With the hospital on lockdown after the Rikers patients escape, Sharpe and Max find themselves in a situation that could cost them their lives; Bloom must put aside her pain to help a patient; Iggy is forced to face his marriage's issues.

Max and Luna make friends in an unexpected place as Max struggles with the realities of being a single father. Meanwhile, Kapoor takes a big step in order to help his family.

Sharpe has an important realization that will affect her career. Meanwhile, Max and Reynolds take on uncharted waters when a young patient comes to New Amsterdam with symptoms of a heart attack.

The doctors stop at nothing to help their patients, following a shocking realization that prompts a change in the hospital. Meanwhile, Reynolds must make an important decision in his career.

Max races against the clock to rearrange the budget when faced with employees going unpaid, while Kapoor is presented with a device that's the future of medicine. Meanwhile, Iggy goes against the norms to prove a diagnosis and Bloom gets an unexpected visitor.

When tasked with turning the opioid epidemic around, Max shuts down the ED and proposes a massive change. Meanwhile, Sharpe goes great lengths to prove a point.

Max, Bloom and Reynolds frantically recount a patient's past encounter that could throw them into a massive lawsuit. Meanwhile, Iggy confronts a local middle school about its teaching policies, and Kapoor lets his superstitions take over.

Max searches for a solution to crowdfunding after his eye-opening appearance in a viral "Go Fund Me" video. Reynolds takes his last laps at the hospital while Kapoor helps a former pilot deal with his life as a paraplegic.

When multiple patients throughout the hospital begin to show similar, alarming symptoms, Sharpe and Bloom scramble to figure out the root of the issue. Iggy tries to create peace for a divorced couple in a dangerous situation and Kapoor experiences a flirtatious encounter. Meanwhile, Max meets a child with a rare muscular disease and desperately tries to get him into the only clinical trial in the country that could extend his life.

New Amsterdam is still reeling from the pandemic as a plane crash lands in the East River. When investigators come to interrogate the flight crew, Iggy fights against the clock to help the pilot uncover the truth. Max tracks down scarce medication after one of his own contracts COVID.

Max is forced to face the heartbreaking consequences of one of his policies. Bloom comes to a startling realization about Iggy.

Max resists an idea that could bring New Amsterdam more revenue. Iggy pushes back on the new telemedicine system. Sharpe uncovers a startling trend while treating a beloved former patient.

Max journeys to Connecticut to bring Luna back to New York, but second-guesses his instincts when he sees her with her grandparents. Bloom takes action to ensure her staff feel safe at work while Reynolds takes a backseat in the cardiac unit. Sharpe struggles to lean on Dr. Cassian Shin while dealing with a family emergency.

When Sharpe notices the hospital's blood supply is running dangerously low, Max concocts a plan to get New Amsterdam out of trouble. Reynolds realizes he has a thing or two to learn from Bloom while making peace with his new position. Iggy helps a patient face their inner demons.

Max is on a mission to fix systemic racism at New Amsterdam. Bloom treats a patient who reminds her that things aren't as they seem. Sharpe is overwhelmed while tending to a family matter. Reynolds tries to keep his composure while treating a father and son.

It's National HIV Testing Day and Max has offered free care to all HIV+ patients who come to New Amsterdam. Bloom and Reynolds butt heads over their opposing bedside manners. Iggy eagerly awaits the return of a friend. Sharpe discovers that she may need more hands on with her niece.

Max is forced to examine the inequities in child labor for women of color. Bloom must deal with an overcrowded ED. Sharpe helps Dr. Agnes Kao with a gut-wrenching diagnosis. Reynolds finds himself experiencing something new on the job.

Max is on a mission to deliver free broadband access. Reynolds treats a young girl with a gunshot wound. Sharpe gives difficult news to a long-time patient. Iggy is immensely proud of his patient's success but worries that he may be getting too close.

Max reckons with New Amsterdam's past. Bloom and Reynolds treat a patient in an unconventional relationship. Sharpe decides to take a stricter approach to parenting her frustrated teenage niece. Iggy tries to connect with a patient desperate to have gastric bypass surgery.

Max implements sweeping changes to hospital sustainability practices. Bloom returns from vacation. Reynolds treats a young patient with deadly heat stroke. Iggy discovers a dangerous situation with a former patient.

A burst pipe plunges the ED into chaos. Iggy counsels two stressed out parents about their child. Gwen and Calvin have some devastating news for Max.

Sharpe offers help to a reluctant Mina. Max is faced with a tough decision about Luna. Bloom and Casey treat a patient who has been hiding a lifelong secret. Iggy finds himself in a very dangerous predicament. Reynolds treats a young heart transplant patient with astonishing symptoms.

Reynolds receives a dramatic offer. Max scours the hospital after he misplaces his wedding ring. Iggy contemplates a serious life change. Bloom learns some potentially life-changing news about Leyla.