Max and Sharpe wake up to a new, more personal dynamic. Iggy calls upon an old contact to help with an explosive situation at the hospital. Bloom begins a tricky dynamic with her new Emergency Department residents. Reynolds finds himself in an awkward position with Dr. Baptiste and his wife, Dr. Lyn Malvo.

Max and Sharpe go public with their relationship at the hospital. The team struggles to handle an overcrowded and understaffed ICU. Iggy's overly critical feedback alienates his residents.

Max advises a young student at a science fair but encounters legal complications with her brilliant invention. Bloom encourages Dr. Shinwari to be more aggressive in the ED. Iggy gets a lesson in humility. Brantley has a surprise for the staff.

Max struggles with a new fiscal reality at the hospital. Dr. Sharpe is on a mission to provide follow-up cancer screenings for patients before it’s too late. Bloom grapples with Dr. Shinwari’s new overnight schedule. Reynolds has an interesting conversation with Dr. Malvo about their future.

Dr. Fuentes continues her quest to remake the hospital in her vision. Max goes the extra mile to help a patient in need. Dr. Sharpe and Iggy find themselves at odds over a very serious issue. Reynolds discovers the importance of personal obligations. Bloom comes to a shocking realization about her mother.

Dr. Reynolds and Dr. Malvo have a heart-to-heart with Dr. Baptiste. Max learns a little more about Sharpe when someone from her past resurfaces. Iggy plays referee between two young patients and their families. Dr. Wilder reconsiders Max’s offer to join the staff.

Max and Bloom are shocked when a deadly ambulance crash reveals a dangerous plan. Dr. Fuentes pressures Iggy to take on patients. Sharpe realizes her own cost-cutting has adversely affected her department. Reynolds, Baptiste and Malvo strive to reach an accord.

Max is faced with a wrenching decision when New Amsterdam falls prey to a massive ransomware attack.

Max takes drastic measures to help several undocumented immigrants after a fire destroys the church where had sought refuge; Sharpe and Malvo assist a patient with a life threatening condition; Reynolds is conflicted about his new position.

As Max and Dr. Sharpe prepare to depart for London, a deadly superbug hits the hospital and draws them back in. Leyla confronts Bloom about the secret she has been hiding. Iggy digs deep to help two grieving parents confront the reality that their son is gone.

Max and Helen settle happily into their new life in London. Dr. Fuentes takes over as medical director with disastrous effects. Bloom helps a patient who thinks he’s cursed. Iggy develops a plan to get his psych patients gainfully employed.

Helen takes the reins at NHS Hampstead Hospital while Max gets creative to help a patient in need. Reynolds reaches a decision about Dr. Malvo. Iggy and Bloom help their patients understand the underlying cause of their stress. Dr. Wilder employs more unconventional techniques.

Max and Helen adjust to sharing their lives and problems, including the challenge of Helen's mother. Bloom and Reynolds treat a family after their horrific car accident lands them in the ED. Iggy and Trevor reach a new understanding in their business relationship.

As the team gathers to mourn the loss of someone dear, Max and Helen realize the extent to which New Amsterdam has changed since they left. Bloom struggles with a big decision while Reynolds decides to take his concerns for his patients to a new level. Dr. Fuentes once again reminds the New Amsterdam team who is in control.

Max formulates a bold plan to help New Amsterdam before it’s too late. Reynolds and Dr. Fuentes fight over the best way to handle a risky surgery. Dr. Wilder asks Dr. Castries for help with a patient with terminal cancer. Iggy helps a father and son deal with vastly different views on a shared trauma.

The New Amsterdam team goes out for a night of karaoke and drinking, but must face the consequences at work the next day. Iggy helps a mysterious patient confront a past trauma. Reynolds and Dr Malvo discuss their future. Leyla gives Lauren some bad news.

The New Amsterdam team continues to deal with the consequences of their big night out. Max and Helen discuss options for their future. Martin finally learns Iggy's secret. Bloom helps Leyla avoid a life-changing situation. Reynolds and Dr. Malvo define their relationship going forward.

Max orchestrates a plan to get Dr. Fuentes terminated from New Amsterdam once and for all. Helen confronts her medical complication. Iggy helps two patients deal with a breakup, which forces him to consider his own marriage. Bloom and Dr. Castries reach an understanding.

Max discovers a fatal flaw in Dr. Fuentes' scheme to purchase the UMI medical clinic, which could be her ultimate undoing. Bloom treats two high school students for life-threatening injuries and uncovers a dangerous situation. Reynolds helps a brother and sister confront a family crisis.

Max discovers the extent to which Dr. Fuentes' cuts are severely damaging New Amsterdam and decides it's now or never. Iggy takes an unconventional approach to reach a young patient in need. Reynolds and Wilder perform a risky, life-saving surgery on unborn twins.

When an elder care facilitate shuts down, New Amsterdam is forced to intake many new patients. Max struggles with his decision to head back to London. Reynolds takes his personal frustrations out on his department with near disastrous results. Iggy's work causes him to reflect on his marriage and personal life.

As a monster hurricane approaches New York, Bloom and the team scramble to put preparations in place. Max and Helen make plans for an intimate New York wedding as she returns from London. Iggy and Martin reach a crossroads. Reynolds finally makes contact with his father.

Bloom, Iggy and Reynolds rally around Max as he deals with the fallout from Helen’s decision. Bloom gives extra space to Leyla, but she’s in for a surprise. Reynolds and Wilder help a young terminal patient realize his dream to star in a Bollywood show. Iggy has a breakthrough with a challenging patient.

Max tests a bold new cost-saving program that could help both New Amsterdam and its neediest patients. Wilder struggles with a patient’s decision to refuse life-saving surgery. Reynolds comes to an important realization about his father’s behaviors. Iggy takes the leap into online dating.

An explosion at a wedding ceremony sends a stream of injured partygoers into New Amsterdam. While Max and Dr. Wilder scramble to find a rare blood type to save the groom, Reynolds and Bloom treat a couple with bizarre injuries. While helping a young girl out of a catatonic state, Iggy learns the truth about the wedding.

Max mandates a personal health day for the staff at New Amsterdam and meets with surprising resistance. Reynolds finds himself intrigued by a persuasive new member of the staff. Bloom struggles with job stress after being taken off an essential medication. Iggy goes on his first date. Max convinces Wilder to get much needed surgery.

Max endeavors to save a nurse who has become the subject of a dangerous malpractice probe. Reynolds goes the extra mile to help a group of patients who are being poisoned in their own building. Bloom makes a startling admission to her sister.

Max goes on a mission to make New York safer. Iggy helps a family come to terms with their deaf child’s inability to communicate.

The New Amsterdam staff grapple with the aftermath of the recent Supreme Court decision on abortion rights. Wilder counsels a woman whose pregnancy puts her life in danger. At Brantley's urging, Max endeavors to find a healthcare solution for out-of-state patients. Bloom reveals monumental news to Reynolds.

Max discovers a revenue-generating department at the hospital that has serious legal implications. Iggy discovers a janitor with otherworldly talents. Reynolds treats a truly inspirational patient and makes plans for his father. Wilder's young patient teaches her not to jump to conclusions in diagnosing.

Reynolds gets creative to help a prospective mother in need. Max takes a chance with Wilder and learns a hard truth. Bloom treats a young brother and sister in dire straits. Iggy reaches a decision about Martin.

Reynolds finds himself caught between a chance for love and an opportunity to spend precious time with his father. Realizing the consequences of her actions, Bloom makes an unexpected move forward with her sister. Max helps an ICU intern struggling with the loss of a patient. Dr. Wilder receives an offer that forces her to choose between her community and her career.

When Helen Sharpe unexpectedly returns to New York, Max escapes to the wilderness on a corporate retreat with Bloom, Dr. Wilder and Iggy. Fun soon turns into catastrophe that threatens a life. Reynolds agrees to perform a risky surgery on a medical school colleague's young son only to be faced with unexpected challenges outside his control.

Max and Wilder face a dilemma over approvals for a revolutionary cancer drug as Max learns a secret about his own bout with cancer. Reynolds goes the extra mile to correct a dire medical situation. Iggy tries desperately to help a woman in need, but finds the system is working against him.

In the series finale, everyone's story reaches a surprising yet inevitable conclusion.